“Chemical” Embryos
نویسندگان
چکیده
منابع مشابه
A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis.
The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). In an effort to understand the role of the maternal compartment in dioxin teratology, we designed a breeding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) an...
متن کاملIdentification of anti‐cancer chemical compounds using Xenopus embryos
Cancer tissues have biological characteristics similar to those observed in embryos during development. Many types of cancer cells acquire pro-invasive ability through epithelial-mesenchymal transition (EMT). Similar processes (gastrulation and migration of cranial neural crest cells [CNCC]) are observed in the early stages of embryonic development in Xenopus during which cells that originate f...
متن کاملAn improved method for chemical devitellinization of X-gal stained Drosophila embryos.
In Drosophila developmental biological studies, X-gal staining is commonly employed to study the spatio-temporal expression of the lacZ reporter gene in the transformed flies or their embryos. Study of the lacZ pattern in embryos often suffers from the lack of an efficient and high yielding technique for devitellinization of X-gal stained embryos. Devitellinization techniques employed during an...
متن کاملOrganization of early frog embryos by chemical waves emanating from centrosomes.
The large cells in early vertebrate development face an extreme physical challenge in organizing their cytoplasm. For example, amphibian embryos have to divide cytoplasm that spans hundreds of micrometres every 30 min according to a precise geometry, a remarkable accomplishment given the extreme difference between molecular and cellular scales in this system. How do the biochemical reactions oc...
متن کاملChemical defences in embryos and juveniles of two common Antarctic sea stars and an isopod
The brooded embryos and/or juveniles of the sea stars Neosmilaster georgianus (Studer, 1885) and Lysasterias perrieri (Studer, 1885) and the isopod Glyptonotus antarcticus (Eights, 1853) were examined for their acceptability using the sympatric sea star Odontaster validus (Koehler, 1906) as a predator. Organic extracts were prepared from embryos of both sea stars and juveniles of Lyasterias per...
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ژورنال
عنوان ژورنال: Nature
سال: 1909
ISSN: 0028-0836,1476-4687
DOI: 10.1038/080507a0